I've been running the cloud version of CS6 for a few months, and in the last several weeks, Photoshop has become incredibly slow, and often gets stuck on the "reading preferences" at startup. I went through all the suggested things, (got rid of bad fonts, downloaded brushes as they were INCREDIBLY slow, and reset some settings to enhance speed), but it's barely made a dent. I already contacted Apple support, and they said it's only an issue with the Adobe software. Also, it reallllllly doesn't like to open .ai documents in psd, which is a problem for me as I need to work in both every day. Any advice?
Run your disk utility to repair permissions, use tools like OnyX to remove stray temp files, check PS' recovery function and memory settings. Contrary to urban legend, Macs are not indestructible and can suffer such systemic issues as well.
Thanks. I actually contacted Adobe directly and they helped me out.