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With the GTX680 and 3 x U2410 monitors, I use 2 monitors for the application, and within Premiere Preferences/Playback/Video Device, I set the third as my external monitor.
I have dabbled with other settings, and this is the best for my working methods.
Sounds like experimenting is the way to find out what's best.
>two from the discrete GPU and the third from the on-board video on my system's motherboard
The discussions may have been directed more at laptops, but I have read that trying to mix brands of graphic adapters can cause major problems... stick with the nVidia, and leave whatever is on the motherboard turned off
Not had any problems mixing adapters so far. I think this is a historic issue that has been solved with newer CPUs and motherboards.