Not using roto bezier. I have some basic frame by frame masking that I need to do. When I click and drag a point to a new position, after I release the mouse, the point moves to a random position FAR from where I dropped it. To rub salt in the wound, I have to Undo (Ctrl+Z) 2-3 times to get it back to the original position (before I moved it). This happens randomly but very often. I've determined that It's not my (wired optical) mouse. This behavior happens with two other wireless mice as well. I am using version CS5 on a Dell Precision machine with a Quadro FX 4800 card and have been dealing with this issue for 2 years now. Any insight is appreciated! Thanks.
Update your graphics driver/ turn off OpenGL in the prefs.
Well, I'll be damned. OpenGL was turned off when I checked. This behavior has continued through about 4-5 driver updates. Lo and behold, the latest driver (released 7/3/2013) seems to have fixed the problem. Thanks Mylenium!