The PDF will be accurate. Likely their pick-up rollers and feed path are accurate. Desktop printers, even slightly spendy ones and the "bizhub" type typically cannot be relied upon for registratino, page to page.
Just be sure to share the design with the printer so they can see what they are getting into. Once they give you the go-ahead, the drift, if any, is on their shoulders.
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There will be alway a kind of drift to to technical limitation. So you have to design the labels so, that the shift is not so obvious, similiar to the bleed problem on normal printers. So keep a distance to the edge, at minimum the maximum os shift you have. And avoid to print the cutting edges (in your case the circles), they will make the shift more visible and you will never be able to target these circles exactly.
Thank you, that makes sense. This is a big step for me - both money-wise and control-wise, so I want to get it as right as I can! I will triple check each one before going to the printer with them!
Thanks for taking time out of your day to answer.
Thank you, I appreciate the advice. I have this insane idea that everthing should just work like I think it should and as you may guess I am often surprised - hahaha! I will triple check that the printer looks my files over carefully for his system.
Thank you again for your help! It was very thoughtful and appreciated.