Try a small test case just to make sure it works for simple cases.
Then you may have to divide-and-conquer by commenting out parts of your app until it works and then try to figure out why there is a part that makes it fail.
I commented out a large array containing 30,000 elements, the release version published in minutes. Thanks for the advice....
I am hoping if I upgrade from 8GB ram to 16GB this will help FlashBuilder publish a release version. I assumed since the Debug Version worked great the release would as well ...lesson learned.