Installed CF10 64 bit on Windows 2008 R2 64bit and I was able to run the admin without issues.
This morning I am unable to access it.... and nothing was changed over the weekend.
Module IIS Web Core
Error Code 0x80070005
Requested URL http://127.0.0.1:80/CFIDE/administrator/index.cfm
Physical Path C:\ColdFusion10\cfusion\wwwroot\CFIDE\administrator\index.cfm
Logon Method Not yet determined
Logon User Not yet determined
I ran WEB server configuration tool using the correct IIS site.
I also noticed the error before the aforementioned is given as
Config Error Cannot read configuration file due to insufficient permissions
Config File \\?\C:\ColdFusion10\cfusion\wwwroot\CFIDE\web.config
but there is no web.config in ~\CFIDE directory