Do you already have projects in multiple languages?
Normally, you create the project in the main language and set context sensitivy. Then you send the project to the translation agency and they send you the translated projects. Then you generate the different language version. The application must then point to the correct directory with the help for that language.
This answer is kind of high level. For information on context sensitivity in general, see: http://www.grainge.org/pages/authoring/calling_webhelp/calling_webhelp.htm