Not enough in your post to be able to help you.
System specs? SSD or conventional hard drive(s)? OS?
How are you scrolling?
New Mac Book Pro, 8 GIG 1600 MHz DDR3 OS 10.8.5 scrolling with bar, sometimes hand tool.
Does it have an SSD or conventional hard drive? How much free space?
For testing you should create and log into a new user account and see if the problem persists. That will narrow the possibilities to either user-related or document/application/system problems of some sort. Is this happening frequently? More than the one file? If it's just the one, try this: Remove minor corruption by exporting