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If you have more than one drive you do not want your cache or source files on the same drive as your applications. The only time I can think of that this would not be the case is when your boot drive is way faster than your other drives and has lots and lots of free space, and I mean way faster. The problem with SSD drives is that they are usually small so they fill up very quickly. It's nice to have the SSD speed but that speed is relatively expensive.
Since you have an additional SSD drive I'd put my cache files there and my media files on the standard drive. If your system SSD drive is more than 70% full and you didn't have a second SSD drive I would still put cache on the standard drive. The only time I would intentionally opt for putting cache on the system drive is when the system drive is a lot faster than any other drive and there is a lot of free space.