Chances are it's an upgrade to something else that caused your colour inconsistency.
What else can you tell us about your computer, printer and your workflow?
Mac OS 10.7.5
Epson Stylus Photo 2200
My workflow? I have calibrated and profiled monitor and printer. I assign profiles to images. I get good monitor/proof agreement from Lightroom and Photoshop. I used to get the same with Illustrator and InDesign. Now I don't. What specifically can I tell you that would help troubleshoot this?
I wonder if new versions of Mac OS and Adobe products are the problem. If I were to buy a new version of InDesign would I get better color printing?
There was a period of time when printing from ID on the Mac invoked the monitor profile in the translation. I don't recall all the details, or which versions were involved, but bu tyou might find somethin useful in a forum search.