http://www.adobe.com/cfusion/knowledgebase/index.cfm?id=tn_18056
A 1450 error has to do with the registry, and even though the
message you get is not exactly what is mentioned in the above
article, I'm almost certain you are experiencing the same issue and
need to clean out the registry as suggested.
We used to have this issue with all versions of CF prior to 7
because until 6 there was no automated purge, and in 6 the purge
never worked properly. MX7 seems to have addressed that issue, but
you would be wiser to use cookies (or DB) for variable storage
anyway.