Thanks for the suggestion. Unfortunately, it did not help. Is there any point in deleting the entire Personal Configuration Folder?
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Yes, clearing the config folder is different from clearing the cache and could clear up issues separate from the ones the cache would catch.
I tested CS5.5 by installing it on a third System C. DW files are still on System A.
Just as on System B, saving a file takes a very long time from CS 5.5 (System C) but is almost instantaneous when using CS3 on System C.
So there is something in the CS 5.5 configuration, including a fresh install,
that is causing a problem with saving a file over the LAN.