Give it a try.
That said, that's a fairly big file and might be unwieldy in one piece. You might want to break it into logical pieces, like chapters, and combine them in a Book (.indb) file.
I though that might be the case. The book has not got chapters, It is a 20,00 item bibliography. It could split at class number breaks, but I wonde rwhether you have any feel for the number of words or characters that it would be best to split it into?
It's a matter of personal preference. 100 pages feels like a good limit for scrolling to me, but how many words that would be is dependent on the page setup and the type size. If you have cross-refernces, though, you'd be best to leave it as a singel document.