You should check with Extensis on that, I think.
Is your undo also disabled in this case? Are you able to Undo/Redo your operations when your save is not working? Kindly check and let us know.
Yes, sometimes the Undo/Redo was also disabled, but at the time we weren’t sure if that was related to the ’Save' issues or not. It seems to be sporadic. If InDesign is restarted sometimes the Undo/Redo will be operational again, but later may suddenly decide to stop working. We haven’t determined any sort of pattern yet.
Re: the ‘Save’ issue…Since my initial posting we have determined that by unchecking the UTC Auto Activate preference for “embedded objects” we are able to once again save files. However, if we do have the 'auto activate for embedded files’ checked, the ‘save’ operation is disabled only for ‘some' files that we open, but not necessarily for all files.