An application patch? An OS patch? What's the version number of each? As in Windows 8.2.03.4.... or whatever.
As Dave says, we're going to need a lot more info to help you. What patch are you referring to? Did you mean the patch for After Effects CS6 to bring it to version 11.0.4? If so, how did you try to apply it?
What OS are you using? What are your other computer specs?
When was the last time it worked properly?
> This is the message we get:
"The application Adobe After Effects CS6 can't be opened. -10810"
That is a Mac OS error.
See this page: http://www.thexlab.com/faqs/error-10810.html
Begin by restarting your computer and starting no applications other than After Effects.