I think that's called an image map, and that can't be done in InDesign.
It could be created in Adobe Illustrator.
Sorry! Image maps can be created in ID.
An image converted to an interactive button with an action going to an URL, I guess would be considered an image map. But you can not export directly into a format that would be useable for an email... or am I missing something?
We agree on the image map but I confess frankly that I do not see the relationship between the question and ID!