Have you tried manually changing your monitor resolution to one of the 'recommended' resolutions? I believe they are 1280 X 720 or 640 X 360 (not sure your monitor can go that low!).
On a hunch, I searched for DPI via the search function in the Windows 8 charms bar and opened the item 'make text and other items larger or smaller'. Under the heading 'Change the size of all items', I found that the slider was set exactly halfway between 'Smaller' and 'Larger' and below this, there was a checkbox titled 'Let me choose the scaling level for all my displays' which was unchecked. I put a check mark in the box and changed the scaling from the existing 'Medium - 125%' to 'Smaller - 100%'. Windows told me I had to reboot the PC to make the changes take effect. On rebooting, my desktop icons were smaller than before, confirmation that the change of DPI had taken effect.
I then made a video test with Adobe Presenter Video Creator with the 'Recording Preferences' setting 'change display resolution during Recording (recommended)' checked and to my satisfaction, ouse clicks no longer appear offset any more. And video quality in the published video looks great.
(N Wales, UK)
Hello. I had the same issue and it was solved too with your solution. Congratulations for your hunch. And thanks !