Have you looked in your Windows Event Logs (specifically, the System log) to see if you're seeing any disk errors?
I have this same problem all the time, and have never figured it out.
I save the first time, it gives me the error.
I try saving it again, and this time it works. Every time, (whenever this error happens), it takes two attempts to save it. But it will always work on the second try.
I don't think it's a given. I've never seen it happen to my knowledge.
What anti-malware solution do you have? And do you have Windows Indexing enabled?
Thx Noel Carboni for your time and effort to assist.
Indeed i have not looked at my log. I will do so.
However; with great reserves; i think (or better hope) i have managed to solve the problem with help of a Senior systemadvisor i met yesterday.
In preferences i changed the active operating Drive (hopefully correct translation from dutch version; Werkschijf) from C:\ towards E:\ (pls keep in mind, all drives are the same type HDD 7200 rpm drives)
I changed memory in use for PS towards 70% and is now 20.000Mb
I then editted and saved 4 (large) files with succes on my D:\ drive without problems.
Hopefully it stays this way
BTW: i must admit Noel, that aroound the arising of my problem i could have installed MBAM antimalware, I think indeed i did so arround that time. But as you can understand, if the solution i have now persists i'm reluctant to try that out. But when the problem returns i will for sure keep this in mind.
Thx for your help.
@ Boo Radley; your problem differs from mine as far as i can see in your post. Nevertheless maybe my solution so far can work for you also or at least set you on the right track. Good luck.