I'm afraid you'll have to be considerably more specific. "Working with tables" is a broad notion that could mean any number of things. "Most effective way" is even more nebulous in that methods and techniques are most often the result of subjective preferences and tendencies, and/or combinations of tools and procedures which might be used one way toward a given objective, and another way toward others.
If you type "table" in the Help search field, you can start reading on intended table workflow. Otherwise, you're always welcome to come back here and get help with more specific scenarios; e.g., "I want this particular result. Would it be better to approach it this way, or that way, or some other way about which I'm unaware...?"