I was updating InDesign CS6 in order to open PageMaker files. While attempting, I received the "update fail, download error, press retry to try again or contact customer support (49) error message. I attempted a couple additional times with no luck. PLEASE ASSIST.
I had a similar problem, most likely caused by MacKeeper which had removed some "not used" information. I reinstalled CS6 and then from within CS6 (under help menu) started update again and all worked fine.