What operating system? In Windows you can move My Documents, Desktop, Downloads, AP cache etc. to other drives. I can't give specific info without knowing your OS.
I am using Windows 8.1. I would like Photoshop to be using the D: data drive to store photos and slide programs I create instead of the C: System Drive that it is currently using. I can move the existing pictures to the D: drive if I can stop Photoshop from working any new material on the C: drive
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A bit more general
Other things to look at are Bridge Cache location (Preferences > Cache)
Things like iTunes and Lightroom libraries, if you have them, and a HUGE space saver is to turn off Hibernate. I think it took 30Gb on my system, and systems can be very problematic when waking from hibernate.
A great app for aiding space saving is WinDirStat which gives you a graphical illustration of any drive. Clicking on any large area will tell you what it is and where located. It's easy to Google how to move it from there.
The one large space you shouldn't move off your boot drive is the Windows PageFile.
This is what it looks like: