It's amazing how many recent posters seem to be under the misconception that there are clairvoyants and mind readers among the forum contributors.
Here's my one-click boilerplate reply:
If you give complete and detailed information about your setup and the issue at hand, such as your platform (Mac or Win), exact versions of your OS, of Photoshop and of Bridge, machine specs, what troubleshooting steps you have taken so far, what error message(s) you receive, if having issues opening raw files also the exact camera make and model that generated them, etc., someone may be able to help you.
Please read this FAQ for advice on how to ask your questions correctly for quicker and better answers:
"station_two" is right, the more information you give us so better the hint can be, ok? But because you are using this forum I understand that you talk about "Photoshop"
Sometimes the "opm.db file" is the culprit. In this case you should delete it.
On the other hand and as much as I regret it and as strange as it may seem I fear it's a challenge for Adobe's Creative Cloud Cleaner Tool.
Sometimes - for whatever reasons - CC doesn't "want" to work. In this case you should CC completely delete and reinstall by help of Adobe Creative Cloud Cleaner Tool. (A try to uninstall by own resources is not enough!)
I quote: ... helps resolve installation problems for Adobe Creative Cloud and Adobe Creative Suite (CS3-CS6) applications. The tool removes installation records for prerelease installations of Creative Cloud or Creative Suite applications. It does not affect existing installations of previous versions of Creative Cloud or Creative Suite applications.
Please use: http://helpx.adobe.com/creative-suite/kb/cs5-cleaner-tool-installation-problems.html and follow the prescribed sequence of operations