Without knowing anything about the file and your procedures nobody can say anything. Such stuff depends on a million factors from how the file was created to what objects are actually on the page. E.g. form elements will prevent persistent rotations since Acrobat has no way of re-arranging them with an auto-layout... Anyway, you need to be much more specific.
Have you asked other users in Document Cloud PDF services
The Cloud forum is not about using individual programs
The Cloud forum is about the Cloud as a delivery & install process
If you will start at the Forums Index https://forums.adobe.com/welcome
You will be able to select a forum for the specific Adobe product(s) you use
Click the "down arrow" symbol on the right (where it says All communities) to open the drop down list and scroll