Of course what is "best" is a matter of opinion and preference. That said, I prefer InDesign, and it is the best general-purpose page layout application available, in my opinion.
InDesign's major competitor would be QuarkXpress.
Thank you John, I do NOT need a big program that can make a lot, but somthing that is easy for the daylig use of making flyvers, brochures, banner and so on for the printing company - is it easy and good for that.?
Well, now you bring "easy" into the question, and that too is a very subjective notion. One of the best things about InDesign is that it makes many complex tasks "easy;" or easier than they would be without it. However, that comes from me, who has been doing page layout for decades and using InDesign since its introduction. For someone of little or no experience, InDesign presents a significant learning curve. If you invest in some books and at least some introductory training, you'll struggle far less than you otherwise might.
If you're going to use InDesign it's vital IMO to get some training in how to use it properly.
Here are some resources you may find useful: