I think LR starts up without any options available and it takes a little while before the options are available. At least this is what I noticed, recently. If you are waiting a long time and they never become available, then perhaps something else is wrong.
Hi, I hope I understand your question correctly. Let's say you load a photo in LR from your desktop and then later remove that photo from your desktop... Lightroom will still show the photo (in Lightroom) but the options/sliders will be greyed out.