I am using LR5.6 on a Windows 7 machine with plenty of memory. LR, CS5 and all of my plug ins have been working just fine. Tonight I've found that if I make any kind of significant adjustments to an image, and the go to "Edit in.." that function does not launch. I can use the Edit in command on an unmodified image, or if I reset the modified image. I have the issue with all of my plug ins, including Photoshop, all of the Nik software, RadLab, and OnOne. I believe that all of the plug ins are current. I've been working with them yesterday and I had no issue. I cannot recall anything that has changed since then, and I have not installed any software. I'm at a loss!! Please help!
I have one other bit of information. The issue only seems to apply to images that I imported this evening. I opened an image that I imported a week ago that I had also edited in LR, and I can get the Edit in option to work just fine.
I have traced the problem to a corrupted profile. When I captured the images in question, I also used Color Cherckr to create a profile for processing. When I apply that profile to the adjustments I make, I can no longer "Edit In". If I use another profile, even one that I created using Color Checkr at a different point in time, I don't have the issue. Something seems to have corrupted the new profile. I will re-create the profile and see if the issue is resolved.