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If you give complete and detailed information about your setup and the issue at hand, such as your platform (Mac or Win), exact versions of your OS, of Photoshop and of Bridge, machine specs, such as total installed RAM, scratch file HDs, video card specs, what troubleshooting steps you have taken so far, what error message(s) you receive, if having issues opening raw files also the exact camera make and model that generated them, etc., someone may be able to help you.
Please read this FAQ for advice on how to ask your questions correctly for quicker and better answers:
If this is something that happened suddenly, the first step would be to trash Photoshop preferences and force it to recreate new ones.
I have checked all help options I can find.
I even asked Photoshop support twice in the last few months, but neither one of the tech's knew how to fix it.
They both claimed they have never heard of such a situation.
All my updates are current.
I am running Photoshop CC.
I am using a PC with Intel, 64 bit system, 8 GB Ram, 700GB free space
I print on Epson Stylus Pro 9900 and Epson Stylus Pro 9880
My custom settings are: Adobe 1998 with perceptual rendering intent.
Randomly, sometimes every couple of months, sometimes everyday, the custom settings default to North American General Purpose ( sRGB with relative rendering intent).
The problem is that I don't know when it reverts until the prints come out looking "off".
I have been using these setting for quite a few years, I did not have this problem before I switched to Photoshop CC. It never randomly switched when I was using Photoshop 6, CS2 or CS4.
Do you even know how to nuke and re-set Photoshop's preferences, colorplak? Your last post seems to reveal that you don't understand what I'm talking about. Here's a link you can click on:
To re-create the preferences files for Photoshop, start the application while holding down Ctrl+Alt+Shift (Windows) or Command+Option+Shift (Mac OS). Then, click Yes to the message, "Delete the Adobe Photoshop Settings file?"
Note: If this process doesn't work for you while you're using a wireless (bluetooth) keyboard, attach a wired keyboard and retry.
Important: If you re-create the preferences by deleting the Adobe Photoshop CC Settings file, make sure that you only delete that file. If you delete the entire settings folder, you also delete any unsaved actions or presets.
Reinstalling Photoshop does not remove the preferences file. Before reinstalling Photoshop, re-create your preferences.
Note for Photoshop 14.1 and later: If you use Generator and reset your Preferences, Generator is disabled. Choose Preferences > Plug-ins to turn it back on.
Video: Julieanne Kost created a video that takes you through two ways of resetting your Photoshop preferences. The manual preference file removal method is between 0:00 - 5:05. The keyboard shortcut method is between 5:05 - 8:18. The video is located here.
Important: Apple made the user library folder hidden by default with the release of Mac OS X 10.7. If you require access to files in the hidden library folder to perform Adobe-related troubleshooting, see How to access hidden user library files.
The point is that preferences files can and often do get corrupted over time. That's why you have to thoroughly delete them and let Photoshop create fresh ones.
It doesn't matter one bit what your preferences are. But if you "have been using these setting for quite a few years", there's a greater chance that they are corrupted by now.