I'm creating a publication in English that will be translated into Pashto and Dari languages which run right to left. I won't be working the translated versions, but I want to set-up a well-organized InDesign master that makes it easy for the designer working on translation to create an alternate layout that runs right-left.
@Daniel – layouting for RTL (right-to-left-direction) would imply one basic setting for the whole document: RTL for the pages. So this would rule out the Alternative Layout feature of InDesign. You simply cannot reset the direction of the pages after a couple of other pages.
If you do not refer to the InDesign feature "Alternate Layout" here, but to an independent InDesign file, the answer is "yes", you can do it. With a "western" version of inDesign this is possible by scripting.
However, using a special plug-in like inTools' World Tools Pro would be the better solution: