Can you please specify the exact error that you are getting? A screenshot of the error dialog might help.
I again re-installed ADE in both my laptop and my desktop and there is a new message on both - "ADE 4.0 has encountered a problem and needs to close." It installs OK but when I try and open it, that is the message I receive.
ADE 4.0 requires .Net framework 4 installed on your PC. Please update it.