You can change key assignments through Preferences-->General-->Keys or Preferences-->ColdFusion-->Profiles-->Keys. Control + O is already mapped to a few commands in specific contexts, but you can override those or specify which contexts you want Control + O to be "Open". See the "When" pull-down at the bottom of the Keys dialog.
Thanks for your input.
I'm unable to discover, specifically, how/where to enter the command for "File Open", there is no place to identify/select/enter that action, do you happen to know how?
Open the Preferences dialog (from the Window menu). Type "keys" in the box in the upper left corner of the dialog. Select "Keys" from the "General" heading in the left-hand pane.
In the box above the listing of commands, type "Open File". The command listing should filter down to just the "Open File..." entry. Click on it to select it. Put the cursor in the "Binding:" box near the bottom of the dialog. Press Control + O to put the key sequence into the box. The "When:" should default to "In Windows" which is probably fine. Click "Apply" and "OK" to close the dialog. Test it out to see if it works.
Thanks so much Carl, that worked perfectly!