Every now and then Adobe Application Manager uninstalls itself for some reason, and when this happens Premiere Pro and After Effects don't work. I then quickly reinstall it and Premiere Pro works fine but After Effects does not. I get this error: "After Effects error: Crash in progress. Last logged message was: <5092> <DynamicLink> <5> F:\Adobe After Effects\Adobe After Effects CS6\Support Files\32\dynamiclinkmanager.exe" and then when I click OK this pops up: "After Effects can't continue: sorry, After Effects has crashed. For After Effects Help and Support...." and so on. I don't know if it matters but at the bottom of this box it says "(0::42)". After that point it says "Adobe After Effects CS6 has stopped working" and the usual pops up. Can you give me any feedback, I don't know what's wrong with it. I heard some things like delete the prefs file and that didn't work. I look forward to hearing from you. Thank you. (and yes, that location is where I have Adobe After Effects installed, my main drive is out of space.)
Without exact system info nobody can tell you anything. Completely running out of disk space on your system root drive alone is problematic due to programs storing temp files and configuration data there.