I have the same problem. The message displayed just as the program stops working also says that "Windows is checking for a solution to the problem" but nothing has happened so far. I have tried uninstalling and reinstalling versions 3.0 and 4.0 to no avail. I hope someone will come up with a solution soon.
Having the same problem in my mac with ADE 4.0. I bought an ebook from Wiley (acsm format) and the app closes with an error when I try to open the book.