Quite often, PS CS6 becomes unresponsive to mouse clicks, i.e., I'll be masking, retouching, painting, etc. and it will just go into a 'pause' mode; I'll have to wait, sometimes a few moments, sometimes several seconds before I can go on with another tool or same tool with further activity. I have 16G ram on new iMac; have quit all other running apps to no avail.
I've dumped prefs, etc.
Running 10.10 now; same problems with previous versions.
Doesn't anybody from Adobe monitor these discussions any more? I see there are several others complaining about this issue, yet it remains unresolved.
I've had to 'downgrade' much of my routine photo repairs to iPhoto in the meantime. Not photoshop, but in a pinch, works fine for many of the simple chores of photo repair/retouching, etc. I've also made much use of On-One plugins too.