Any errors or warnings in the CF ISAPI log file located \ColdFusion10\config\wsconfig\N\ isapi_redirect.log ?
You reinstalled CF10 to update 12. Did you perform the manual step running WSCONFIG tool to increment the ISAPI dll IIS connector file? Perhaps the date stamp of \ColdFusion10\config\wsconfig\N\ isapi_redirect.dll will be indicator to know.
No errors in the ISAPI log. We have reinstalled several more times since the last time I posted. We have two identical instances of
the install, running in HyperV. One regularly gets the white-screen-of-death and the other does not. The one difference is, on the instance with no trouble, we never have more than 50 simultaneous connections. The glitchy instance seems to be blowing up at around 200 simultaneous connections. Any thoughts would be appreciated.
For the CF server taking more load and getting errors perhaps you do well to apply some CF tomcat tuning. The official blog heading is CF11 however details apply to CF10 as well:
If you like some other insight into the matter of CF tomcat tuning I did a talk and demo. Here is recording: