I have the same problem. Thought it was my intuos 4 driver. Installed and reinstalled but nothing work. Bought a new Intuos Pro, and the same problems occur. This is frustrating.
The provided links above take care of the keyboard shortcut issues. As far as Wacom missing prefs this is the information I received from tech support. I haven't actually tried this yet. I don't want to wipe out my current prefs unless I need to change something.
Thank you for contacting Wacom Customer Care. We would need to perform a clean driver install on your computer. Please make sure that you are uninstalling the previous driver in your computer prior to reinstalling a new driver as this would create corrupted driver files.
Also, please unplug the tablet from the computer before starting these instructions. Please follow these steps:
Open your Applications folder and locate any Tablet or Wacom Tablet folders you have Use the Utility in each of these folders and click ‘Remove’ under ‘Tablet Software’
Once the software is removed, restart the computer
Once this is complete, download and install the latest 6.3.10 driver from:
As always, make sure your tablet is connected directly to your computer. Avoid using USB hubs, keyboard/monitor ports, or docking stations with the tablets, as they can cause inconsistent behavior. Also, please make sure that you are connecting the USB cable directly to the USB port at the back of your computer.
Thank for this posting. I was going nuts trying to figure out the problem. It works normally now.