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Set the fill color of the rectangle holding your image to Black, and the fill color of the image itself (select with the white arrow) to Paper.
This will only work on grayscale and black-and-white images; then again, those are the only logical candidates to make negative.
In case "it is not working": there is a difference between a full color image containing only gray pixels and a real grayscale image. The former cannot be changed in ID, the latter can.
Thanks, but can't get it to work. I imagine using a Fill etc doesn't give the result that an 'invert' command does in Photoshop.
Quark may be long gone in common usage, but it did have some better functions than InDesign!
Objection! It is not the task of a layout tool to process digital images. If you invert the original in PS, you don't even need to place it.