This not possible with Presenter.
Adobe Presenter Engineering Team
Is it possible with Captivate?
The above scenario is not possible in Captivate too. You can shuffle the answers but cannot restrict any option from shuffling.
Thank you for responding.
Although I have a very limited experience with Captivate and with Presenter I am not sure whether this suggestion will work. Can you split up your A-D questions separate from the E question and thus only shuffle A-D in a script? For example, if I were coding this in Flash (ActionScript 3.0) I would create two separate arrays, one for the A-D questions and one for the E questions/answers and perform the necessary logic against those two distinct arrays. That way you can always keep your second array consistently appearing in the same place in your quiz.