Topic or subject titles should be clear, pertinent and concise so that individual users can tell at a glance if they can help or not.
That field is not for attempting to fit your entire question in there.
Please keep this in mind next time you post. Thank you.
Is your Photoshop CS5 updated to 12.1?
Are you on Yosemite 10.10.1 or Yosemite 10.10.2?
Did you apply the recent Epson software 2.1.9 update?
What type of file is it (file format)? What bit depth and what color space?
Note that this is boilerplate text.
If you give complete and detailed information about your setup and the issue at hand,
such as your platform (Mac or Win),
exact versions of your OS, of Photoshop (not just "CS6", but something like CS6v.13.0.6) and of Bridge,
your settings in Photoshop > Preference > Performance
the type of file you were working on,
machine specs, such as total installed RAM, scratch file HDs, total available HD space, video card specs, including total VRAM installed,
what troubleshooting steps you have taken so far,
what error message(s) you receive,
if having issues opening raw files also the exact camera make and model that generated them,
if you're having printing issues, indicate the exact make and model of your printer, paper size, image dimensions in pixels (so many pixels wide by so many pixels high). if going through a RIP, specify that too.
someone may be able to help you (not necessarily this poster, who is not a Windows user).
a screen shot of your settings or of the image could be very helpful too.
Please read this FAQ for advice on how to ask your questions correctly for quicker and better answers:
Yosemite has indeed caused many Photoshop CS5 headaches.
First see if Epson has issued any updated drivers. Download and Install.
Be sure CS5 is updated to 12.0.4
If that doesn't work, reset Prefs by holding down the cmd-opt-shift keys and start Photoshop. You should see a dialog asking to delete the settings files.
Thirdly, you can uninstall and reinstall CS5 and reinstall the updates. Hopefully that fixes anything that damaged the your CS5 install.
Thank you. The Photoshop update and resetting the preferences solved the grayed out Color, Grayscale selection in the Print settings box. But I'm still getting the black ink overlay. I'll call Epson on Monday. Thanks for your help.