This thread was initially posted in the Adobe Captivate forum and has been moved to the InDesign forum.
Depends what you mean by "eBook". It's a generic name for a number of formats, and each type has advantages (features) and disadvantages. For example, it's easy to produce a PDF from an InDesign print file and keep all the design features, but it may be difficult to sell in this format through traditional outlets. You can produce ePubs from InDesign (fixed and reflowable text types) and also subsequently convert them into formats for selling through the Amazon store, but the InDesign design needs to be set up in a particular way and design features may be limited.
This new book will give you a very good overview: http://www.amazon.com/Digital-Publishing-Adobe-InDesign-CC/dp/0133930165/ref=sr_1_1?ie=UTF 8&qid=1419073988&sr=8-1&keywords=Digital+Publishing+with+Adobe+InDesign+CC%3A+Moving+Beyon d+Print+to+Digital&pebp=1419073989609
And there's an InDesign ePub forum.