Nobody can tell you anything without exact system info, project details, footages used, screenshots of the timeleine and a gigazillion otehr things. Just saying that it doesn't work is not in any way useful.
Core i7 4770K @ 4.5GHz
Asus Sabertooth Z87
Corsair Vengeance DDR3 1600MHz 16GB
Samsung 840PRO 256GB (OS & where Adobe software is installed)
Seagate 2TB 7200RPM HDD (Project Files)
WD 1TB 7200RPM HDD (Scratch Disk)
Seagate 80GB 7200RPM HDD (Exported Files)
Hitachi 5TB 7200RPM HDD (Raw video)
The original video was recorded in DXTory with the Lagarith Lossless codec, at varying FPS from 20 to 60. Audio is recorded separately, but in same container. Different files when editing though. 1920x1080 video. Audio is in the MP3 container, PCM 48000Hz, 16 bit for game, 24 bit for voiceover, one stereo for game sound, one mono for voiceover.
Will that be all?
AE is crap at dealing with MP3 or Lagarith. Convert your files.