InDesign should work fine on Mac OS Yosemite. But, every time Mac has released a major update like this, we have seen trouble. This trouble is seen when the OS is directly updated, over the top of the existing OS, as opposed to be being a fresh install on a clean system. These updates tend to break existing files by mangling permissions. Generally, if InDesign stops working after such an OS update, the only step that is required to get it working again is to reset the preferences:
1. Quit InDesign, then relaunch the application and immediately hold down the following key combinations for your OS:
- Mac OS X: CTL+OPT+CMD+Shift
- Windows: CTL+ALT+Shift
2. A dialog appears, asking “Delete InDesign Preference Files?” ClickYes.
If InDesign continues to not work, then the next most common solution in these situations is to uninstall and reinstall the product.
InDesign CS5.x is NOT supported on Yosemite. It may run, but if problems occur, you are alone as CS5.5 is not compatible with Yoosemite. Minimum for Yosemite is CS6, mime for Retina Displays is CC.
Another problem is installing: Any application from Adobe does not work properly if it is migrated from any other computer or backup, you need to install it from the original installer.
CS5.5 is most certainly NOT supported on Yosemite. Additionally, in place operating system upgrades are nothing short of a crapshoot.
You are on your own here but you can try to uninstall, run the CC cleaner tool, and then reinstall. This still carries no assurance that it will work. Even a clean install of Yosemite is no guarantee.