I am nit familiar with a lot of the Adobe applications, but for those that I am familiar there would be no difference in the software. The differences should only lie in the keyboard changes to how to interact with the software.
Which Adobe apps do you use in particular?
The differences should be minor. Many people (myself included) and companies have Adobe workflows which include both PC and Mac. Negligible differences in my experience.
Keyboard shortcuts vary and there can be font differences between PC and Mac (e.g. may affect InDesign)
I mainly use Illustrator CC, Photoshop CC, Indesign CC.