Thank you for trying to help.
Unfortunately, I unchecked the box as suggested but there has been no change in behavior, LR still resets color profile to come bluish standard, when I exit LR the profile reverts to more neutral one I have calibrated.
Below is the system info I get from LR, it mentions 'failed OpenGL support'. My late 2010 MacBookPro has never given me this issue on prior versions of LR.
Lightroom version: CC 2015.1 [ 1025654 ]
License: Creative Cloud
Operating system: Mac OS 10
Version: 10.10 
Application architecture: x64
Logical processor count: 4
Processor speed: 2.5 GHz
Built-in memory: 8,192.0 MB
Real memory available to Lightroom: 8,192.0 MB
Real memory used by Lightroom: 426.4 MB (5.2%)
Virtual memory used by Lightroom: 1,126.6 MB
Memory cache size: 50.2 MB
Maximum thread count used by Camera Raw: 2
Camera Raw SIMD optimization: SSE2
Displays: 1) 1680x1050
Graphics Processor Info:
Check OpenGL support: Failed
Vendor: NVIDIA Corporation
Version: 3.3 NVIDIA-10.0.31 310.90.10.05b12
Renderer: NVIDIA GeForce GT 330M OpenGL Engine
How are you calibrating your screen? This shouldn't happen for sure but perhaps the specific calibration tool you use has some strange interactions with LR.
In the past I had a similar problem- I profiled my monitor with a Spyder colorimiter.
The Spyder profile looked good until the Nvidia graphics card changed it back to something else.
There is an option in the Nvidia control panel to- Choose how color is set- "Other applications control color settings." This must be selected as the default. (NOT "Use Nvidia settings.")
THank you guys. I'll give it a shot tonight...
Couldn't find a NVIDIA control panel anywhere on the Mac. I have checked off Automatic Graphics switching in the Energy Saver tab, what it does it has neutralized my color profile in a manner similar to what Lightroom is doing. Now I'm still an unhappy camper but at least my eye adapts to the 'common' color profile in/outside of LR and the transition between the two is not painfully evident. Still not ideal, though...
But I read that my graphics card, a
- NVIDIA GeForce GT 330M
is unsupported by LR. I suppose that's the issue, here... I thought I could put off upgrading my late-2010 for a while longer after having put an SSD in to replace the HD (much faster indeed), but screen management is a real issue at this stage. (Though it was not with LR5 before moving to CC...)
Sorry, my rant about Nvidia control panel only refers to windows systems!
Noting your mention of Graphics switching, you might be on the right track.
There is some advice on Mac forums if you search-
Well, it seems that 2015.1 has fixed the issue? Don't know exactly but calibration profiles are back where they should be. Anguish over. Would like to understand exactly what happened, for forensic pleasure...
Looks like you had the same issue as posted here:
This issue is "fixed" in LR 6.1 and CC 2015.1 as per Adobe employee:
"This was fixed in the CC 2015.1 / 6.1 Update."