It should "work" regardless of GPU. The question is, will the GPU accelerate it and make it fast enough to be useable? I don't know. It's not on the approved list of cards. What version of AE do you have? Are you looking to buy a computer or something? Knowing why you're asking the question can help us form a better answer.
I'll be using CC 2015, I'm looking to buy a Mac to run it on but after some research have discovered that it is hard to find one with the correct GPU to run AE with Ray-Trace 3D renderer. I could go the PC route of course but I prefer Macs so if there is a solution I am keen to find out.
The ray-traced renderer is obsolete. Go with the more powerful 3d tool the AE team is recommending instead.
Alternatively, get a third-party tool such as Element 3d, Zaxwerks Invigorator, or Mettle's ShapeShifter that will use a Mac's GPU. They'll be faster than the ray-traced renderer would have been.
Alternatively, go with Windows 7. It's excellent! Very stable. AE works very well in it. And you can get a lot more computing bang for your buck.
Thanks thats a great help, I will look further into this.