I would say you will have to try it.
There is currently officially NO support for Windows 10 / IIS 10 for coldfusion at the moment.
No. Coldfusion is at this moment NOT supported on Windows 10 public release. I've tried it, and had to roll back to Win8.1.
I'd be interested in hearing if Adobe has any plans to update the installer / connectors; as a long time CF developer, I'm finding this situation rather lame to put it politely.