same problem with InDesign CC and Bridge
Your first problem is you MOVED to Win 10. Hasn't anyone learned that you never upgrade Windows on the first release of a new version. Been like that for 23 years.
Windows 10 is full of bugs and changes no one, no software company, has caught up with.
If it Ain't broke stop trying to Fix it. Seems everything was working just fine with your previous version of Windows.
I have a similar setup as you do, Lightroom 6 instead of CC, and don't have any problems with the Intuos 5 and the v6.3.13w3 driver ... make sure that all the defaults for mapping on the pen are being used ... especially that Use Windows Ink is selected. Note I don't have a problem with CS6, Indesign, Ai and various other programs from other vendors.
Despite what other people say Windows 10 is stable and a lot faster than Win 7/8.1 and I have no issues at all ... but then again I don't have AMD GPU.
Sorry Edited because there was one other thing I forgot to mention.
With the Wacom drivers it is imperative that you remove ALL User Preferences when you update the driver, there is a Wacom utility to Backup the preferences first, remove them and them restore them after you have installed the new driver. It is a known bug.
I was forced to move back to Lightroom 5.4 and Photoshop CS, because there is no thus lag. Thank you for tip about "Use Windows Ink" - after unchecking this option everything works fine )