I am running Lightroom 6 (not the CC version, the standalone one) on an iMac running El Capitan.
I generally found the Apple Magic Mouse - which I generally LOVE - uncomfortable with Lightroom. Seems to move a bit too quickly and the scrolling that works great with Mac app is incredibly FAST in Lightroom.
I have been using a Logitech M510 Wireless USB mouse for Lightroom (and when I run Windows for the same reasons), but while the mouse works great with Windows 10, in Lightroom it feels very uncomfortable. And a lot of the mouse clicks either don't register or I feel like I have to keep pressing the mouse button longer to get LR to acknowledge it.
I have tried checking the Logitech website, but seems like I have the latest software for El Capitan.