I'm having the same problem. In my case, I export an epub3 file directly from Adobe InDesign. By default, the file opens in ADE on export. ADE spins (not responding, high CPU). I have to force quit. I didn't try removing the TOC. If I export the same InDesign doc as epub 2.0.1, it opens fine.
I'm also on Win 10 pro. My ADE version is 22.214.171.124054.
Having the exact same problem.
Windows 10 Pro, ADE 4.5 and any ePUB 3 (tried several different files from different sources) cause ADE to go into "Not Responding" and I have to kill the task.
I downloaded ADE 3.0 and tested that. The files open but they're broken so there is clearly an issue with 4.5.
Downloaded AZARDI and all the ePUB 3 files open without a hitch.
This is clearly an issue with ADE that needs to get sorted out.
Example in dropbox now gives an error 404, file not found