Could be the shortcuts are being used by another program or the OS....
If it's not a system override (if you're on a Mac choose System Preferences from Apple menu, and click Keyboard, then Shortcuts), than it might be a change in InDesign.
In InDesign check that you are still using the Defaults Shortcuts:
- Choose Edit > Keyboard Shortcuts
- And check that the Preset is set to [Default]
Wanted to say thanks for trying to help figure this out. Believe it or not, it turns out that the culprit was the keyboard itself. Option key was fried. Go figure.
[personal info removed by moderator]
Haah! The good old sticky keys (or worse faulty). Glad to hear you got it sorted!