What is your operating system?
I'm using El Capitan 10.11
Start by restoring your InDesign preferences:
Problems with keyboard modifiers are almost never the problem with InDesign itself. It's almost always because third-party software or sometimes system software are grabbing keystrokes. To test this, restart your computer (if possible, disable startup software). Open InDesign first before any other application, and usually the problem goes away.
If not, launch InDesign in a new user to remove yourself from competing software or possible system corruption.
You can try the steps:
1. If you are using Google Chrome and if there are any extensions installed on the browser, try to remove them and restart machine and check.
2. Are you using any anti virus like Webroot, If yes then go to preferences and pause secure keyboard.
3. You can also try to restart MAC in safe mode and check the performance, if that works try restarting the machine and check again.
As it turned out i did an open rebuild (Cmd + Ctrl + Opt + Shift) which in turn reset my workspace but hey the main aspects are working again.
Thanks everyone for your prompt response's much appreciated,